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Collaboration

Academic, clinical, and industry partnerships with the TEMPO@UVA Laboratory.

The TEMPO@UVA Laboratory actively engages in collaborative research with investigators across academic institutions, clinical partners, and industry. Our multidisciplinary approach — spanning mitochondrial bioenergetics, non-invasive physiological measurement, and translational exercise trials — suits projects that require rigorous physiological phenotyping in humans or bench-level bioenergetic measurement.

What we offer

High-Resolution Respirometry

Oroboros O2k and NextGen O2k with fluorometry. SUIT protocols for permeabilized fibers and isolated mitochondria — skeletal muscle, cardiac muscle, adipose, PBMCs, T-cells, and more.

In Vivo NIRS Assessments

The use of NIRS-based oxygen sensors to measure muscle oxidative capacity and reoxygenation kinetics.

Human Physiology Testing

CPET with metabolic cart, isokinetic dynamometry, DXA body composition, resting energy expenditure — protocols built for randomized and longitudinal designs.

Analytical & Statistical Support

Mixed-effects longitudinal modeling, AUC calculations, and reproducible research pipelines.

Current collaborative partners

Partner / group	Institution	Focus
Sumeet Khetarpal, MD, PhD	UVA School of Medicine Robert M. Berne Cardiovascular Research Center	Mitochondrial bioenergetic phenotyping in preclinical models of cardiometabolic diseases
Guillaume Spielmann, PhD	LSU, School of Kinesiology	Immunoenergetics — PBMC/T-cell mitochondrial function & exercise immunology
Timothy Allerton, PhD	Pennington Biomedical Research Center	Mitochondrial phenotyping in preclinical model of HFpEF to examine the impact of exercise and novel therapeutics on skeletal muscle and cardiac mitochondria and exercise tolerance.
Efthymios Papadopoulos, PhD	LSU, School of Kinesiology	Cancer & sarcopenia · osteosarcopenia in colorectal cancer surgery
Bernard Rees, PhD	University of New Orleans	Comparative mitochondrial physiology · Gulf killifish model
Erich Gnaiger, PhD	Oroboros Instruments, Innsbruck, Austria	NextGen O2k method development · Visiting Scientist program
MitoEAGLE Consortium	Standardization of mitochondrial respiratory terminology	International
SWIFT Trial Writing Committee	Geisinger · NYU · UT Southwestern · Ethicon	Bariatric surgery & total knee arthroplasty outcomes

How to initiate a collaboration

The best initial contact is a brief email to bi9n@virginia.edu.

Email the lab

The research question or specific aim you would like to address

The population or tissue involved

The measurement or capability you would like from our lab

The timeline and any funding mechanisms in place or planned

Grant collaborations: Dr. Irving is available to serve as Co-Investigator, Sub-Award PI, or consultant on federal and foundation applications. Please allow at least 8 weeks of lead time before the sponsor deadline for meaningful integration into the project.

Data sharing & reproducibility

The lab is committed to open science and reproducible research. Where possible, we deposit data and share analysis code